Tumor tissue levels of tissue inhibitor of metalloproteinase-1 as a prognostic marker in primary breast cancer.

@article{Schrohl2004TumorTL,
  title={Tumor tissue levels of tissue inhibitor of metalloproteinase-1 as a prognostic marker in primary breast cancer.},
  author={Anne-Sofie Schrohl and Mads Nikolaj Holten-Andersen and Harry A. Peters and Maxine P Look and Marion E. Meijer-van Gelder and Jan G. M. Klijn and Nils Bruenner and John A. Foekens},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 7},
  pages={2289-98}
}
PURPOSE In the present study, we investigated the association between tumor tissue levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and prognosis in patients with primary breast cancer and analyzed whether TIMP-1 may be useful as a prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1). EXPERIMENTAL DESIGN In cytosolic extracts of 2984 primary breast tumors, total levels of TIMP-1 were determined using an… CONTINUE READING