Tumor tissue concentrations of the proteinase inhibitors tissue inhibitor of metalloproteinases-1 (TIMP-1) and plasminogen activator inhibitor type 1 (PAI-1) are complementary in determining prognosis in primary breast cancer.

@article{Schrohl2003TumorTC,
  title={Tumor tissue concentrations of the proteinase inhibitors tissue inhibitor of metalloproteinases-1 (TIMP-1) and plasminogen activator inhibitor type 1 (PAI-1) are complementary in determining prognosis in primary breast cancer.},
  author={Anne-Sofie Schrohl and Ib Jarle Christensen and Anders Navrsted Pedersen and Vibeke E. D. Jensen and Henning T. Mouridsen and Gillian Murphy and John A. Foekens and Nils Brunner and Mads Nikolaj Holten-Andersen},
  journal={Molecular & cellular proteomics : MCP},
  year={2003},
  volume={2 3},
  pages={164-72}
}
The purpose of this study was to investigate the association between tumor tissue levels of total tissue inhibitor of metalloproteinases-1 (TIMP-1) and prognosis in patients with primary breast cancer and to analyze whether measurement of TIMP-1 in tumor extracts added prognostic information to that obtained from measurements of urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 (PAI-1). An established sandwich enzyme-linked immunosorbent assay was thoroughly… CONTINUE READING