Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.

  title={Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.},
  author={David de Sancho and Diego Mour{\~a}o-S{\'a} and Olivier P. Joffre and Oliver Schulz and Neil C. Rogers and Daniel J Pennington and James R. Carlyle and Caetano Reis e Sousa},
  journal={The Journal of clinical investigation},
  volume={118 6},
The mouse CD8alpha+ DC subset excels at cross-presentation of antigen, which can elicit robust CTL responses. A receptor allowing specific antigen targeting to this subset and its equivalent in humans would therefore be useful for the induction of antitumor CTLs. Here, we have characterized a C-type lectin of the NK cell receptor group that we named DC, NK lectin group receptor-1 (DNGR-1). DNGR-1 was found to be expressed in mice at high levels by CD8+ DCs and at low levels by plasmacytoid DCs… CONTINUE READING
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