Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis.

@article{Durntez2010TumorTI,
  title={Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis.},
  author={Maika Dur{\'a}ntez and Catherine Fayolle and Noelia Casares and Virginia Bels{\'u}e and Jos{\'e} Ignacio Riezu-Boj and Pablo Sarobe and Jes{\'u}s Prieto and Francisco Borr{\'a}s-Cuesta and Claude Leclerc and Juan J Lasarte},
  journal={Vaccine},
  year={2010},
  volume={28 44},
  pages={7146-54}
}
Staphylococcus epidermidis releases a complex of at least four peptides, termed phenol-soluble modulins (PSM), which stimulate macrophages to produce proinflammatory cytokines via activation of TLR2 signalling pathway. We demonstrated that covalent linkage of PSM peptides to an antigen facilitate its capture by dendritic cells and, in combination with different TLR ligands, can favour the in vivo induction of strong and persistent antigen-specific immune responses. Treatment of mice grafted… CONTINUE READING