Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C.

  title={Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C.},
  author={Simon S. Brack and Michela Silacci and Manfred T Birchler and Dario Neri},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={12 10},
BACKGROUND The targeted delivery of bioactive molecules with antibodies specific to tumor-associated antigens represents a promising strategy for improving the efficacy of tumor therapy. The large isoform of tenascin-C, an abundant glycoprotein of the tumor extracellular matrix, is strongly overexpressed in adult tissue undergoing tissue remodeling, including wound healing and neoplasia, and has been implicated in a variety of different cancers while being virtually undetectable in most normal… CONTINUE READING
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