Corpus ID: 13128090

Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.

@article{Bradley2001TumorTB,
  title={Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.},
  author={M. Bradley and N. L. Webb and F. H. Anthony and P. Devanesan and P. Witman and S. Hemamalini and Madhavi C. Chander and S. Baker and L. He and S. Horwitz and C. S. Swindell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 10},
  pages={
          3229-38
        }
}
  • M. Bradley, N. L. Webb, +8 authors C. S. Swindell
  • Published 2001
  • Medicine, Biology
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • Certain natural fatty acids are taken up avidly by tumors for use as biochemical precursors and energy sources. We tested in mice the hypothesis that the conjugation of docosahexaenoic acid (DHA), a natural fatty acid, and an anticancer drug would create a new chemical entity that would target tumors and reduce toxicity to normal tissues. We synthesized DHA-paclitaxel, a 2'-O-acyl conjugate of the natural fatty acid DHA and paclitaxel. The data show that the conjugate possesses increased… CONTINUE READING
    Lipid-Based Anticancer Prodrugs
    5

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