Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.

@article{Bradley2001TumorTB,
  title={Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.},
  author={Matthews O. Bradley and Nigel L. Webb and Forrest H. Anthony and P. Paul Devanesan and Philip A. Witman and S. Hemamalini and Monica Chander and Sharyn D. Baker and Lina He and Susan Band Horwitz and Charles S. Swindell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 10},
  pages={3229-38}
}
Certain natural fatty acids are taken up avidly by tumors for use as biochemical precursors and energy sources. We tested in mice the hypothesis that the conjugation of docosahexaenoic acid (DHA), a natural fatty acid, and an anticancer drug would create a new chemical entity that would target tumors and reduce toxicity to normal tissues. We synthesized DHA-paclitaxel, a 2'-O-acyl conjugate of the natural fatty acid DHA and paclitaxel. The data show that the conjugate possesses increased… CONTINUE READING