Tumor targeting and microenvironment-responsive nanoparticles for gene delivery.

@article{Huang2013TumorTA,
  title={Tumor targeting and microenvironment-responsive nanoparticles for gene delivery.},
  author={Shixian Huang and Kun Shao and Yuyang Kuang and Yang Liu and Jianfeng Li and Sai An and Yubo Guo and Haojun Ma and X I He and Chen Jiang},
  journal={Biomaterials},
  year={2013},
  volume={34 21},
  pages={5294-302}
}
A tumor targeting nanoparticle system has been successfully developed to response to the lowered tumor extracellular pH (pHe) and upregulated matrix metalloproteinase 2 (MMP2) in the tumor microenvironment. The nanoparticles are modified with activatable cell-penetrating peptide (designated as dtACPP) that's dual-triggered by the lowered pHe and MMP2. In dtACPP, the internalization function of cell-penetrating peptide (CPP) is quenched by a pH-sensitive masking peptide, linking by a MMP2… CONTINUE READING

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