Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125.

@article{Kim2011TumorTA,
  title={Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125.},
  author={Young-Hwa Kim and Jongho Jeon and Su Hyun Hong and Won-Kyu Rhim and Yun-Sang Lee and Hyewon Youn and June-Key Chung and Myung Chul Lee and Dong Soo Lee and Keon Wook Kang and Jwa-Min Nam},
  journal={Small},
  year={2011},
  volume={7 14},
  pages={
          2052-60
        }
}
Radioactive iodine-labeled, cyclic RGD-PEGylated gold nanoparticle (AuNP) probes are designed and synthesized for targeting cancer cells and imaging tumor sites. These iodine-125-labeled cRGD-PEG-AuNP probes are stable in various conditions including a range of pHs and high salt and temperature conditions. These probes can target selectively and be taken up by tumor cells via integrin αvβ3-receptor-mediated endocytosis with no cytotoxicity. The probes show a significant increase in the avidity… CONTINUE READING
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