Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity.

@article{Gill2014TumortargetedPI,
  title={Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity.},
  author={J. Gill and P. Loadman and S. Shnyder and P. Cooper and J. Atkinson and G. Ribeiro Morais and L. Patterson and R. Falconer},
  journal={Molecular pharmaceutics},
  year={2014},
  volume={11 4},
  pages={
          1294-300
        }
}
Development of therapeutic strategies for tumor-selective delivery of therapeutics through exploitation of the proteolytic tumor phenotype has significant scope for improvement of cancer treatment. ICT2588 is a peptide-conjugated prodrug of the vascular disrupting agent (VDA) azademethylcolchicine developed to be selectively hydrolyzed by matrix metalloproteinase-14 (MMP-14) within the tumor. In this report, we extend our previous proof-of-concept studies and demonstrate the therapeutic… Expand
17 Citations
A Novel Theranostic Strategy for MMP-14–Expressing Glioblastomas Impacts Survival
Proteases in cancer drug delivery.
Protease‐activated prodrugs: strategies, challenges, and future directions
Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models
Involvement of ER stress and reactive oxygen species generation in anti-cancer effect of CKD-516 for lung cancer
...
1
2
...

References

SHOWING 1-10 OF 48 REFERENCES
Prodrugs for improving tumor targetability and efficiency.
Tumour endoproteases: the cutting edge of cancer drug delivery?
Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide–paclitaxel conjugate in mice with breast cancer
  • Qizhen Cao, Z. Li, +4 authors X. Chen
  • Chemistry, Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • 2008
Vascular-disrupting agents in oncology
Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies
...
1
2
3
4
5
...