Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy.

  title={Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy.},
  author={Liang Xu and Kathleen F. Pirollo and Esther H. Chang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={74 1-3},
A long-standing goal in gene therapy for cancer is a stable, low toxic, systemic gene delivery system that selectively targets tumor cells, including metastatic disease. Progress has been made toward developing non-viral, pharmaceutical formulations of genes for in vivo human therapy, particularly cationic liposome-mediated gene transfer systems. Ligand-directed tumor targeting of cationic liposome-DNA complexes (lipoplexes) is showing promise for targeted gene delivery and systemic gene… CONTINUE READING