Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes.

@article{Ogris2003TumortargetedGT,
  title={Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes.},
  author={Manfred Ogris and Greg F. Walker and Thomas Blessing and Ralf Kircheis and Markus Wolschek and Ernst Wagner},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2003},
  volume={91 1-2},
  pages={
          173-81
        }
}
Surface-shielded DNA delivery systems have been synthesized with virus-like characteristics that target gene expression into distant tumor tissues. Polyethylenimine (PEI)/DNA complexes ('polyplexes') conjugated with the cell-binding ligand transferrin (Tf) or epidermal growth factor (EGF) were used to achieve receptor-mediated endocytosis. The surface charge of the complexes was masked by covalently linking PEI to polyethylene glycol (PEG). Three alternatives for generating these surface… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 112 CITATIONS, ESTIMATED 59% COVERAGE

Gene Therapy Protocols

  • Methods in Molecular Biology™
  • 2008
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Preparation of PEGylated cationic nanoliposome-siRNA complexes for cancer therapy.

  • Artificial cells, nanomedicine, and biotechnology
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2003
2018

CITATION STATISTICS

  • 4 Highly Influenced Citations

Similar Papers

Loading similar papers…