Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide.

@article{Wood2008TumortargetedGD,
  title={Tumor-targeted gene delivery using molecularly engineered hybrid polymers functionalized with a tumor-homing peptide.},
  author={Kris C. Wood and Samira M Azarin and Wadih Arap and Renata Pasqualini and Robert Langer and Paula T Hammond},
  journal={Bioconjugate chemistry},
  year={2008},
  volume={19 2},
  pages={403-5}
}
Before gene therapy can be used in clinical settings, safe and efficient DNA delivery systems must be developed to overcome a range of extra- and intracellular transport barriers. As a step toward the development of a modular, multifunctional gene delivery system to overcome these diverse barriers, we have developed a family of linear-dendritic "hybrid" polymers which contain functionalities for tissue targeting, minimization of nonspecific interactions, endosomal buffering, and DNA binding… CONTINUE READING
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