Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.

@article{Sun2008TumortargetedDD,
  title={Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.},
  author={Conroy Sun and Chen Fang and Zachary R. Stephen and Omid Veiseh and Stacey J. Hansen and Donghoon Lee and Richard G. Ellenbogen and Jim Olson and Miqin Zhang},
  journal={Nanomedicine},
  year={2008},
  volume={3 4},
  pages={495-505}
}
AIMS This study examines the capabilities of an actively targeting superparamagnetic nanoparticle to specifically deliver therapeutic and MRI contrast agents to cancer cells. MATERIALS & METHODS Iron oxide nanoparticles were synthesized and conjugated to both a chemotherapeutic agent, methotrexate, and a targeting ligand, chlorotoxin, through a poly(ethylene glycol) linker. Cytotoxicity of this nanoparticle conjugate was evaluated by Alamar Blue cell viability assays, while tumor-cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates.

American journal of nuclear medicine and molecular imaging • 2014
View 3 Excerpts
Highly Influenced

Nanomaterials for biomedical applications.

Nanomedicine • 2008
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…