Tumor-targeted Salmonella. Highly selective delivery vectors.

  title={Tumor-targeted Salmonella. Highly selective delivery vectors.},
  author={David Bermudes and Ben Low and John M. Pawelek},
  journal={Advances in experimental medicine and biology},
Genetically engineered Salmonella offer an intriguing new approach to selectively target solid tumors, including melanoma, lung, colon, breast, kidney and liver. These bacteria target tumors after systemic administration and selectively replicate within them. Specificity for tumors is often more than 1,000 times greater than for any other tissue. Auxotrophic mutations make these bacteria highly safe and form the basis for maintaining tumor specificity. An altered lipid greatly reduces the… CONTINUE READING

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