Tumor suppressors: enhancers or suppressors of regeneration?

  title={Tumor suppressors: enhancers or suppressors of regeneration?},
  author={Jason H. Pomerantz and Helen M. Blau},
  volume={140 12},
Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essential for tissue regeneration. This is in contrast to suggestions that tumor suppression is a trade-off… CONTINUE READING

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