Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx.

@article{Park2009TumorSP,
  title={Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx.},
  author={Sung-Gyoo Park and Ji Young Min and Chan Siu Chung and Antony Hsieh and Guhung Jung},
  journal={Cancer letters},
  year={2009},
  volume={282 2},
  pages={229-37}
}
The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stability of HBx protein. Overexpression of p53 protein reduced the level of HBx protein and downregulation of p53 protein by siRNA increased the level of HBx protein in HCC cell lines… CONTINUE READING

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