Tumor suppressor pRB functions as a co‐repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription

@article{Gupta2003TumorSP,
  title={Tumor suppressor pRB functions as a co‐repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription},
  author={Sunita Gupta and Mai X. Luong and Sylvia A Bleuming and Angela Miele and Michael Luong and Daniel W. Young and Erik S. Knudsen and Andre J. van Wijnen and Janet L Stein and Gary S. Stein},
  journal={Journal of Cellular Physiology},
  year={2003},
  volume={196}
}
The CCAAT displacement protein (CDP‐cut/CUTL1/cux) performs a key proliferation‐related function as the DNA binding subunit of the cell cycle controlled HiNF‐D complex. HiNF‐D interacts with all five classes (H1, H2A, H2B, H3, and H4) of the cell‐cycle dependent histone genes, which are transcriptionally and coordinately activated at the G1/S phase transition independent of E2F. The tumor suppressor pRB/p105 is an intrinsic component of the HiNF‐D complex. However, the molecular interactions… Expand
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