Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

@inproceedings{Zhang2014TumorSP,
  title={Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD},
  author={Cen Zhang and Juan Liu and Rui Wu and Yingjian Liang and Meihua Lin and Jia Liu and Chang S. Chan and Wenwei Hu and Zhaohui Feng},
  booktitle={Oncotarget},
  year={2014}
}
Cancer cells display enhanced glycolysis to meet their energetic and biosynthetic demands even under normal oxygen concentrations. Recent studies have revealed that tumor suppressor p53 represses glycolysis under normoxia as a novel mechanism for tumor suppression. As a common microenvironmental stress for tumors, hypoxia drives the metabolic switch from the oxidative phosphorylation to glycolysis, which is crucial for survival and proliferation of cancer cells under hypoxia. The p53's role and… CONTINUE READING

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