Tumor suppressor p53 is required to modulate BRCA1 expression.

  title={Tumor suppressor p53 is required to modulate BRCA1 expression.},
  author={P. Arizti and Lei Fang and I. -S. Park and Yuzhi Yin and E. Solomon and Toru 3 Ouchi and Stuart A. Aaronson and Sam W. Lee},
  journal={Molecular and cellular biology},
  volume={20 20},
Individuals carrying mutations in BRCA1 or p53 genes are predisposed to a variety of cancers, and both tumor suppressor genes have been implicated in DNA damage response pathways. We have analyzed a possible functional link between p53 and BRCA1 genes. Here we show that BRCA1 expression levels are down-regulated in response to p53 induction in cells that undergo either growth arrest, senescence, or apoptosis. Physiological stimuli, such as exposure to DNA-damaging agents, also result in… CONTINUE READING

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