Tumor suppressor p53 gene mutation in squamous cell carcinoma of the larynx.

@article{Sarkar1996TumorSP,
  title={Tumor suppressor p53 gene mutation in squamous cell carcinoma of the larynx.},
  author={F. H. Sarkar and Wael Ali Sakr and Yue Wei Li and J Roger Jacobs and John D. Crissman},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={1996},
  volume={5 3},
  pages={201-5}
}
Using polymerase chain reaction (PCR)-SSCP (single-strand conformation polymorphism) and PCR-DNA sequencing analysis, we screened 61 cases of laryngeal squamous cell carcinoma for mutations in exons 5-8 of the p53 gene. Mutations were found in 31.3% (19 of 61) of the laryngeal cancers. Seventeen of 19 (84.2%) cases showing p53 gene mutations were stage III and IV, which suggests that p53 gene mutation is a rather late event in tumor development and is involved in the progression of laryngeal… CONTINUE READING