Tumor-suppressor p53: implications for tumor development and prognosis.

  title={Tumor-suppressor p53: implications for tumor development and prognosis.},
  author={David G Kirsch and Michael B. Kastan},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={16 9},
The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell death. Loss of p53 function during tumorigenesis can lead to inappropriate cell growth, increased cell survival, and genetic instability. p53 gene mutations occur in approximately half of all malignancies from a wide range of human tumors. In some tumor types, these p53 mutations are associated with poor prognosis and treatment failure. Based… CONTINUE READING