Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors.

@article{Li2008TumorSP,
  title={Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors.},
  author={Junan Li and Blake M. Warner and Bruce Cordell Casto and Thomas Knobloch and Christopher Weghorst},
  journal={Molecular carcinogenesis},
  year={2008},
  volume={47 10},
  pages={733-8}
}
The prevalence of p16(INK4A)/Cdkn2a genetic alterations in human oral cancers indicates that the p16 gene could be a potent and appropriate target for novel intervention. While chemically induced hamster cheek pouch (HCP) tumors are regarded as an appropriate surrogate model for human oral cancers because of their similarities to human oral cancers in both histology and genetics, little is known about the genetic events in the p16 gene in the HCP tumor model. The purpose of this study was to… CONTINUE READING