Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue.

@article{Giangreco2013TumorSM,
  title={Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue.},
  author={Angeline Antonio Giangreco and Avani Vaishnav and Dennis Wagner and Antonio Finelli and Neil Fleshner and Theodorus H van der Kwast and Reinhold Vieth and Larisa Nonn},
  journal={Cancer prevention research},
  year={2013},
  volume={6 5},
  pages={483-94}
}
MiR-100 and miR-125b are lost in many cancers and have potential function as tumor suppressors. Using both primary prostatic epithelial cultures and laser capture-microdissected prostate epithelium from 45 patients enrolled in a vitamin D3 randomized trial, we identified miR-100 and -125b as targets of 1,25-dihydroxyvitamin D3 (1,25D). In patients, miR-100 and -125b levels were significantly lower in tumor tissue than in benign prostate. Similarly, miR-100 and -125b were lower in primary… CONTINUE READING
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