Tumor suppressor genes.

@article{Levine1990TumorSG,
  title={Tumor suppressor genes.},
  author={Arnold J. Levine},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={1990},
  volume={12 2},
  pages={60-6}
}
The retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types. Several types of cancers have been shown to be derived from cells that have extensively mutated both alleles of one or both of these genes, resulting in a loss-of-function mutation. In the case of the p53 gene, this mutational process appears to occur in two steps, with the first mutation at the p53… CONTINUE READING

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