Tumor suppressor genes and medulloblastoma

  title={Tumor suppressor genes and medulloblastoma},
  author={Philip H. Cogen and Jeffrey D. McDonald},
  journal={Journal of Neuro-Oncology},
Although primary intracranial neoplasms are the most common type of solid cancer in children, little is known about their etiology at the molecular genetic level. Recently, studies have shown that a class of genes known as tumor suppressors play an important role in the origin of several different types of human tumors, including those located in the central nervous system (CNS). Using a variety of techniques, selective loss of DNA sequences has been identified in tissue specimens from children… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 44 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

Shattuck-Eidens D: A strong candicate for the breast and ovarian cancer susceptibility gene BRCA1

Y Miki, J Swensen
View 1 Excerpt

Clonal expansion of p 53 mutant cells is associated with brain tumor progression

D Sidransky, I Mikkelsen, K Schwechheimer
Nature • 1992

Similar Papers

Loading similar papers…