Tumor suppressor functions of FBW7 in cancer development and progression.

  title={Tumor suppressor functions of FBW7 in cancer development and progression.},
  author={Zhiwei Wang and Hiroyuki Inuzuka and Jiateng Zhong and Lixin Wan and Hidefumi Fukushima and Fazlul H. Sarkar and Wenyi Wei},
  journal={FEBS letters},
  volume={586 10},
FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream substrates and how dysregulation of Fbw7-mediated proteolysis of these substrates… CONTINUE READING

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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

  • H. Inuzuka, S. Shaik, +8 authors A.W
  • Nature 471,
  • 2011
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