Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma.

@article{Barrett2013TumorSF,
  title={Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma.},
  author={Caitlyn W. Barrett and Wei Ning and Xiao Dong Chen and Jesse J. Smith and M. Kay Washington and Kristina E. Hill and Lori A Coburn and Richard M Peek and R. Pravin Chaturvedi and Keith T Wilson and Raymond F. Burk and Christopher Sept. Williams},
  journal={Cancer research},
  year={2013},
  volume={73 3},
  pages={
          1245-55
        }
}
The glutathione peroxidases, a family of selenocysteine-containing redox enzymes, play pivotal roles in balancing the signaling, immunomodulatory, and deleterious effects of reactive oxygen species (ROS). The glutathione peroxidase GPX3 is the only extracellular member of this family, suggesting it may defend cells against ROS in the extracellular environment. Notably, GPX3 hypermethylation and underexpression occur commonly in prostate, gastric, cervical, thyroid, and colon cancers. We took a… CONTINUE READING

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