Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.

  title={Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.},
  author={Irene Esposito and Hany Kayed and Shereen Keleg and Thomas Giese and Elizabeth Sage and Peter Schirmacher and Helmut Friess and Joerg Kleeff},
  volume={9 1},
SPARC-like protein 1 (SPARCL1), a member of the SPARC family, is downregulated in various tumors. In the present study, the expression and localization of SPARCL1 were analyzed in a wide range of nontumorous and neoplastic pancreatic tissues by quantitative reverse transcription-polymerase chain reaction, laser capture microdissection, microarray analysis, and immunohistochemistry. For functional analysis, proliferation and invasion assays were used in cultured pancreatic cancer cells… CONTINUE READING
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