Tumor suppressor function of Rab25 in triple-negative breast cancer.

  title={Tumor suppressor function of Rab25 in triple-negative breast cancer.},
  author={Ji-Ming Cheng and Lisa D Volk and Deepak Kumar Mummidavarapu Janaki and Sudhir Bhargav Vyakaranam and Sophia Ran and Krishna A Rao},
  journal={International journal of cancer},
  volume={126 12},
Rab proteins are a group of ubiquitously expressed proteins that are responsible for intracellular transport of vesicles. Recent evidence has shown that certain Rab proteins are involved in the pathogenesis of cancer. We have recently shown that Rab25 is lost in a large fraction of breast cancer samples, particularly those derived from hormonally insensitive tumors. We have further investigated the role of Rab25 by re-expressing Rab25 in tumorigenic cell lines and measuring the impact on tumor… CONTINUE READING
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