Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

@article{Copp2011TumorSA,
  title={Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.},
  author={Jean-Philippe Copp{\'e} and Francis Rodier and Christopher K. Patil and Adam Freund and P. Desprez and Judith Campisi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 42},
  pages={36396-403}
}
Cellular senescence suppresses cancer by preventing the proliferation of cells that experience potentially oncogenic stimuli. Senescent cells often express p16(INK4a), a cyclin-dependent kinase inhibitor, tumor suppressor, and biomarker of aging, which renders the senescence growth arrest irreversible. Senescent cells also acquire a complex phenotype that includes the secretion of many cytokines, growth factors, and proteases, termed a senescence-associated secretory phenotype (SASP). The SASP… CONTINUE READING
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