Tumor suppressor activity of neural cell adhesion molecule in colon carcinoma.

@article{Roesler1997TumorSA,
  title={Tumor suppressor activity of neural cell adhesion molecule in colon carcinoma.},
  author={John M Roesler and Eri S. Srivatsan and Farhad Moatamed and Juergen Peters and Edward H. Livingston},
  journal={American journal of surgery},
  year={1997},
  volume={174 3},
  pages={251-7}
}
BACKGROUND AND AIMS Neural Cell Adhesion Molecule (NCAM) is a well-characterized member of the immunoglobin superfamily. The structure of NCAM is similar to the tumor suppressor Deleted in Colon Carcinoma (DCC). NCAM has been found in some epithelial tissues and plays a role in tumorigenesis of some cancers. The purpose of the present study was to determine if NCAM is present in normal human colon. Once its presence was established, its function as a tumor suppressor was investigated. METHODS… CONTINUE READING