Corpus ID: 2263127

Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.

  title={Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.},
  author={K. Yamada and M. Araki},
  journal={Journal of cell science},
  volume={114 Pt 13},
  • K. Yamada, M. Araki
  • Published 2001
  • Medicine, Biology
  • Journal of cell science
  • PTEN (also known as MMAC-1 or TEP-1) is one of the most frequently mutated tumor suppressors in human cancer. It is also essential for embryonic development. PTEN functions primarily as a lipid phosphatase to regulate crucial signal transduction pathways; a key target is phosphatidylinositol 3,4,5-trisphosphate. In addition, it displays weak tyrosine phosphatase activity, which may downmodulate signaling pathways that involve focal adhesion kinase (FAK) or Shc. Levels of PTEN are regulated in… CONTINUE READING
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