Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration.

@article{Chen2003TumorSM,
  title={Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration.},
  author={Jiyuan Chen and Sunil Chada and Abner B Mhashilkar and Joseph M. Miano},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2003},
  volume={8 2},
  pages={220-9}
}
Abnormalities in smooth muscle cell (SMC) proliferation and differentiation underlie the pathogenesis of proliferative vascular diseases. MDA-7 (HUGO approved symbol IL24) is a unique gene, originally identified as a tumor suppressor and more recently shown to have cytokine activity. MDA-7/IL24 has been implicated in apoptosis and cellular differentiation in tumor cells and in tumor invasion/metastasis in clinical specimens-properties central to SMC remodeling during proliferative vascular… CONTINUE READING