Tumor suppressor FUS1 signaling pathway.

  title={Tumor suppressor FUS1 signaling pathway.},
  author={Lin Qin Ji and J. L. A. Roth},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  volume={3 4},
FUS1 is a novel tumor suppressor gene identified in the human chromosome 3p21.3 region where allele losses and genetic alterations occur early and frequently for many human cancers. Expression of FUS1 protein is absent or reduced in the majority of lung cancers and premalignant lung lesions. Restoration of wt-FUS1 function in 3p21.3-deficient non-small cell lung carcinoma cells significantly inhibits tumor cell growth by induction of apoptosis and alteration of cell cycle kinetics. Here we… CONTINUE READING


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Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21. 3 homozygous Journal of Thoracic Oncology

  • M Kondo, L Ji, C Kamibayashi
  • Volume 3, Number
  • 2008

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