Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

  title={Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis},
  author={Seung-Hyun Ro and Xiang Xue and Sadeesh Kumar Ramakrishnan and Chun-Seok Cho and Sim Namkoong and Insook Jang and Ian A. Semple and Allison Ho and H. Park and Yatrik M. Shah and Jun Hee Lee},
The mTOR complex 1 (mTORC1) and endoplasmic reticulum (ER) stress pathways are critical regulators of intestinal inflammation and colon cancer growth. Sestrins are stress-inducible proteins, which suppress both mTORC1 and ER stress; however, the role of Sestrins in colon physiology and tumorigenesis has been elusive due to the lack of studies in human tissues or in appropriate animal models. In this study, we show that human SESN2 expression is elevated in the colon of ulcerative colitis… CONTINUE READING
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The Regulation of AMPK 1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

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