Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells.

@article{Iwasaki2015TumorsuppressiveMI,
  title={Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells.},
  author={Tatsuya Iwasaki and K. Tanaka and M. Kawano and I. Itonaga and H. Tsumura},
  journal={International journal of oncology},
  year={2015},
  volume={46 4},
  pages={
          1543-50
        }
}
  • Tatsuya Iwasaki, K. Tanaka, +2 authors H. Tsumura
  • Published 2015
  • Medicine, Biology
  • International journal of oncology
  • MicroRNAs (miRNAs) regulate cell proliferation and differentiation by silencing gene expression at the post-transcriptional level; moreover, by binding to the complementary sequences within mRNAs in cancer cells, these small non-coding RNA molecules can function as tumor suppressors or oncogenes. Recently, the dysregulation of miRNA expression has been found to be associated with increased tumorigenicity and poor prognosis in several cancer types, including osteosarcoma (OS). To identify… CONTINUE READING
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