Tumor-suppressive and promoting function of transforming growth factor beta.

  title={Tumor-suppressive and promoting function of transforming growth factor beta.},
  author={Lu-Zhe Sun},
  journal={Frontiers in bioscience : a journal and virtual library},
  • Lu-Zhe Sun
  • Published 2004 in
    Frontiers in bioscience : a journal and virtual…
Transforming growth factor beta (TGFbeta) is a multifunctional polypeptide. Its role in carcinogenesis can be either suppressive or promoting depending on tumor developmental stages and cellular context. During the early phase of epithelial tumorigenesis, TGFbeta inhibits primary tumor development and growth by inducing cell cycle arrest and possibly apoptosis. However, in late stages of progression, as tumor cells evade the growth inhibition by TGFbeta due to inactivation of its signaling… CONTINUE READING
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