Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma.

@article{Teng2011TumorSA,
  title={Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma.},
  author={Brian Lew Teng and Kathryn E. Hacker and Shufen Chen and Anthony R. Means and W. Kimryn Rathmell},
  journal={Molecular oncology},
  year={2011},
  volume={5 5},
  pages={465-74}
}
Pin1 specifically recognizes and catalyzes the cis-trans isomerization of phosphorylated-Ser/Thr-Pro bonds, which modulate the stability, localization, and function of numerous Pin1 targets involved in tumor progression. However, the role of Pin1 in cancer remains enigmatic as the gene is located on chromosome 19p13.2, which is a region subject to loss of heterozygosity in several tumors. Since Pin1 protein is frequently under-expressed in kidney cancer, we have explored its role in human clear… CONTINUE READING

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