Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death

@article{Salah2016TumorSI,
  title={Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death},
  author={Firas Subhi Salah and Matthias Ebbinghaus and Vijaykumar Yogesh Muley and Zifei Zhou and K R D Al-Saadi and Manuela Pacyna-Gengelbach and Gregory A O'Sullivan and Helene Betz and Rainer Koenig and Z-q Wang and Rolf Br{\"a}uer and Iver Petersen},
  journal={Cell Death and Disease},
  year={2016},
  volume={7},
  pages={e2205-}
}
GABARAP belongs to an evolutionary highly conserved gene family that has a fundamental role in autophagy. There is ample evidence for a crosstalk between autophagy and apoptosis as well as the immune response. However, the molecular details for these interactions are not fully characterized. Here, we report that the ablation of murine GABARAP, a member of the Atg8/LC3 family that is central to autophagosome formation, suppresses the incidence of tumor formation mediated by the carcinogen DMBA… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

Nature Cell Biology • 2001
View 4 Excerpts
Highly Influenced

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Proceedings of the National Academy of Sciences of the United States of America • 1993
View 5 Excerpts
Highly Influenced

Oxidative stress and autophagy: the clash between damage and metabolic needs

G Filomeni, D De Zio, F. Cecconi
Cell Death Differ • 2015
View 3 Excerpts
Highly Influenced

Self-consumption: the interplay of autophagy and apoptosis

Nature Reviews Molecular Cell Biology • 2014
View 4 Excerpts
Highly Influenced

The LC3 interactome at a glance.

Journal of cell science • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…