Tumor suppression by small molecule inhibitors of translation initiation

@inproceedings{Chen2012TumorSB,
  title={Tumor suppression by small molecule inhibitors of translation initiation},
  author={Longtang L Chen and Bertal H Aktas and Yibo Wang and Xiaoying He and Rupam Sahoo and Nancy Zhang and S{\'e}verine Denoyelle and Eihab Kabha and Hong-Wei Yang and Revital Yefidoff Freedman and Jeffrey G. Supko and Michael Chorev and Gerhard Wagner and Jose A Halperin},
  booktitle={Oncotarget},
  year={2012}
}
Translation initiation factors are over-expressed and/or activated in many human cancers and may contribute to their genesis and/or progression. Removal of physiologic restraints on translation initiation causes malignant transformation. Conversely, restoration of physiological restrains on translation initiation reverts malignant phenotypes. Here, we extensively characterize the anti-cancer activity of two small molecule inhibitors of translation initiation: #1181, which targets the eIF2∙GTP… CONTINUE READING

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