Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

Abstract

p27Kip1 and p21Cip1 are cyclin dependent kinase inhibitors which can arrest cell proliferation and p27 is a tumor suppressor gene. To address the mechanism of tumor suppression by p27 and to determine if p21 has a tumor suppressor phenotype, we utilized the two stage skin carcinogenesis model on p27 and p21 knockout mice. In this model, initiation, which… (More)
DOI: 10.1038/sj.onc.1202840

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@article{Philipp1999TumorSB, title={Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis}, author={Jeannette Philipp and Khoa Vo and Kay E. Gurley and Kristy Seidel and Christopher J. Kemp}, journal={Oncogene}, year={1999}, volume={18}, pages={4689-4698} }