Tumor suppression by cell competition through regulation of the Hippo pathway.

  title={Tumor suppression by cell competition through regulation of the Hippo pathway.},
  author={Chiao-lin Chen and Molly C. Schroeder and Madhuri Kango-Singh and Chunyao Tao and Georg Halder},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 2},
Homeostatic mechanisms can eliminate abnormal cells to prevent diseases such as cancer. However, the underlying mechanisms of this surveillance are poorly understood. Here we investigated how clones of cells mutant for the neoplastic tumor suppressor gene scribble (scrib) are eliminated from Drosophila imaginal discs. When all cells in imaginal discs are mutant for scrib, they hyperactivate the Hippo pathway effector Yorkie (Yki), which drives growth of the discs into large neoplastic masses… CONTINUE READING


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Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap

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  • 2010
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