Tumor suppression and normal aging in mice with constitutively high p53 activity.

  title={Tumor suppression and normal aging in mice with constitutively high p53 activity.},
  author={Susan M. Mendrysa and Kathleen A. O'Leary and Matthew K. McElwee and Jennifer Michalowski and Robert N. Eisenman and Douglas A. Powell and Mary Perry},
  journal={Genes & development},
  volume={20 1},
The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compare the effects of decreased levels of Mdm2 and hence increased p53 activity on tumorigenesis and life span in mice. Here we report that mice with decreased levels of Mdm2 are… CONTINUE READING
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