Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer

  title={Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer},
  author={Thomas Blankenstein and Zhen-zhu Qin and Klaus Uberla and Werner M{\"u}ller and H. K. Rosen and H. D. Volk and Tibor Diamantstein},
  journal={The Journal of Experimental Medicine},
  pages={1047 - 1052}
The tumor necrosis factor alpha (TNF-alpha) gene was introduced by retroviral gene transfer into the TNF-alpha-insensitive tumor cell line J558L. Production of 40 pg/ml TNF-alpha by clone J2T12 consistently did not change the growth rate in vitro, but drastically suppressed tumor growth when injected into syngeneic BALB/c mice. Within 2 wk, 90% of the mice inoculated with J558L cells developed a tumor, but none of the mice injected with J2T12 did so. Within the observation period (greater than… CONTINUE READING

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