Tumor-suppressing pathways in cystic pancreatic tumors.

  title={Tumor-suppressing pathways in cystic pancreatic tumors.},
  author={Berthold Gerdes and Anja Wild and Judith Wittenberg and Peter Josef Barth and Annette Ramaswamy and Michael Kersting and Jutta Luettges and Guenter Kloeppel and Detlef Klaus Bartsch},
  volume={26 1},
INTRODUCTION AND AIMS Serous and mucinous cystic pancreatic tumors have different clinical behavior. We evaluated whether they also have genotypic differences by analyses of the tumor suppressor genes, p16INK4a, p53, and DPC4. METHODOLOGY Seven serous cystadenomas (SCA) and seven malignant mucinous cystadenocarcinomas (MCC) were analyzed for alterations in the tumor suppressor genes p16INK4a, p53, and DPC4 by single-strand conformational variant analysis, direct sequencing, and… CONTINUE READING
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