Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes.

@article{Thayanithy2014TumorstromalCT,
  title={Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes.},
  author={Venugopal Thayanithy and Elizabeth Louise Dickson and Clifford J. Steer and Subbaya Subramanian and Emil Lou},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2014},
  volume={164 5},
  pages={359-65}
}
Tunneling nanotubes (TnTs) represent a novel mechanism by which intercellular components such as proteins, Golgi vesicles, and mitochondria can be transferred from cell to cell in the complex tumor microenvironment. Here, we report data showing that microRNAs (miRNAs) are transferred through TnTs in osteosarcoma (OS) and ovarian cancer as in vitro model systems. miRNA array analysis demonstrated significant upregulation of miR-19a in OS tumors resected from human patients, and differential… CONTINUE READING
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