Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.

@article{Nitzki2010TumorSW,
  title={Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.},
  author={Frauke Nitzki and Arne Zibat and Simone Koenig and Mark G J M Wijgerde and Albert Rosenberger and Felix H. Brembeck and Per-Ole Carstens and Anke Frommhold and Anja Uhmann and Stefan Klingler and Julia Reifenberger and Tobias Pukrop and Fritz Aberger and Walter J. Schulz-Schaeffer and Heidi Ann Hahn},
  journal={Cancer research},
  year={2010},
  volume={70 7},
  pages={2739-48}
}
Basal cell carcinoma (BCC) is the most common skin tumor in humans. Although BCCs rarely metastasize, they can cause significant morbidity due to local aggressiveness. Approximately 20% of BCCs show signs of spontaneous regression. The understanding of molecular events mediating spontaneous regression has the potential to reduce morbidity of BCC and, potentially, other tumors, if translated into tumor therapies. We show that BCCs induced in conditional Ptch(flox/flox)ERT2(+/-) knockout mice… CONTINUE READING

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