Tumor-stimulated release of tumor necrosis factor-alpha by human monocyte-derived macrophages.

@article{Demarco1992TumorstimulatedRO,
  title={Tumor-stimulated release of tumor necrosis factor-alpha by human monocyte-derived macrophages.},
  author={Richard A Demarco and Jeffery E Ensor and Jeffrey D. Hasday},
  journal={Cellular immunology},
  year={1992},
  volume={140 2},
  pages={304-18}
}
Tumor necrosis factor-alpha (TNF) release by monocytes and macrophages may be an important determinant of the physiologic response of the host to neoplastic disease; however, the mechanisms which regulate TNF release by macrophages in hosts with neoplastic diseases are poorly understood. The purpose of this study was to determine if cell membranes and growth medium from human leukemia cell lines and solid tumor cell lines induced TNF release by cultured human blood monocyte-derived macrophages… CONTINUE READING