Tumor stem cell niches: a new functional framework for the action of anticancer drugs.

@article{Baguley2006TumorSC,
  title={Tumor stem cell niches: a new functional framework for the action of anticancer drugs.},
  author={B. C. Baguley},
  journal={Recent patents on anti-cancer drug discovery},
  year={2006},
  volume={1 1},
  pages={121-7}
}
  • B. C. Baguley
  • Published 2006 in Recent patents on anti-cancer drug discovery
Newer treatments of advanced human cancer increasingly rely on combinations of drugs that have quite different actions yet unexpectedly potentiate each other's effects. Recent research in stem cell biology suggests a model for tumors in which tumor growth is governed by the generation of cells from tumor cell niches rather than from the population as a whole. Each niche contains a population of tumor stem cells supported by a closely associated vascular bed comprising mesenchyme-derived cells… CONTINUE READING